Was looking to buy an 06 accord ex with the 4cyl and 5 speed. Has about 160,000 miles on the clock. How reliable are the manuals compared to the autos, and what should I expect going into something like this? Thanks in advance.

 

I know Hondas are better than most but it's a 15 year old car, don't expect to have a trouble free experience for 5 yrs. Make sure all fluids are up to date, inspect rubber components - bushings, hoses, etc..
My 06 V6 luckily was mostly trouble free - brakes, tires, oil, 5 batteries, starter and a few drive belts. Driver side window is slightly off track but does not affect closing or opening.

Other than that, random stuff be prepared to spend some $ every now and then.